Pre-Implantation Genetic Screening (PGS), also known as Pre-Implantation Genetic Testing for Aneuploidy (PGT-A), is a specialized genetic test used during in vitro fertilization (IVF) to screen embryos for chromosomal abnormalities before they are transferred into the uterus. PGT-A aims to improve the chances of successful implantation and reduce the risk of miscarriage by selecting embryos with the correct number of chromosomes. Here’s an overview of how PGT-A typically works:
PGT-A is usually performed as part of the IVF process. The steps include:
The embryos are allowed to develop in the laboratory for a few days until they reach a suitable stage for biopsy. This is typically at the blastocyst stage, around day 5 or 6 after fertilization.
A small number of cells are carefully removed from each embryo for genetic testing. This biopsy is usually performed using a laser or fine needle, and it does not harm the embryo’s development.
The cells obtained from the embryo biopsy are analyzed to determine their chromosomal makeup. Techniques such as next-generation sequencing (NGS) or array comparative genomic hybridization (aCGH) are used to identify embryos with the correct number of chromosomes (euploid embryos) and exclude those with chromosomal abnormalities (aneuploid embryos).
Following genetic testing, only euploid embryos are considered for transfer into the uterus during the IVF cycle. Euploid embryos have a higher chance of implantation and a lower risk of miscarriage compared to aneuploid embryos.
One or more euploid embryos are selected for transfer into the woman’s uterus. The embryo transfer procedure is typically performed a few days after the biopsy, once the uterine lining is deemed optimal for implantation.
Any remaining euploid embryos that are not transferred during the IVF cycle may be cryopreserved (frozen) for future use.
Pre-Implantation Genetic Screening (PGT-A/PGS) is a valuable tool for couples undergoing IVF who are at increased risk of having embryos with chromosomal abnormalities. By selecting euploid embryos for transfer, PGT-A can enhance the chances of a successful pregnancy and reduce the likelihood of miscarriage. It is essential to discuss the potential benefits, risks, and ethical considerations with a healthcare provider to determine if PGT-A is the right option.
At SG IVF, our experienced team is dedicated to providing comprehensive and personalized care to help you make informed decisions about your reproductive options. We are committed to supporting you through every step of your fertility journey with expertise and compassion.
Our team of highly experienced doctors and medical professionals is here to provide you with top-notch care throughout treatment
Our team of highly experienced doctors and medical professionals is here to provide you with top-notch care throughout treatment
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